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Remote monitoring device detects AMD progression

Reviewed by Angela Christine Yim, BA; and Yannis Mantas Paulus, MD, FACS A handheld, standalone device provides easy, fast, and comfortable remote monitoring for patients with dry age-related macular degeneration (AMD), according to Angela Yim, BA; and Yannis Mantas Paulus, MD, FACS. Yim is a student at the University of Michigan Medical School in Ann Arbor. […]

Getting a better handle on IOP control

Reviewed by Jed Lusthaus, MBBS, MPH, FRANZCO Contrary to what one might expect, the highest IOP spikes can occur 1 week after implantation of the iStent device (Glaukos) viatrabecular bypass surgery, not on postoperative day 1. In addition, investigators have found that hemoglobin video imaging (HVI) may enhance our understanding of IOP control and aqueous […]

Gene therapy trial highlights RPGR-associated X-linked RP

Reviewed by Michel Michaelides, MDA gene therapy for a common and severe form of retinitis pigmentosa (RP), RPGR-associated X-linked RP, botaretigene sparoparvovec (MeiraGTx Holdings plc and Janssen Pharmaceuticals), demonstrated improvements in retinal sensitivity and visual function compared with controls and had a manageable adverse event profile, according to Michel Michaelides, MD, from the UCL Institute […]

Pipeline reveals bright future for combating diabetic eye disease

Reviewed by David S. Boyer, MD When treating diabetic retinopathy (DR), the current approach for physicians remains medical management, specifically maintaining control of blood sugar, blood pressure, and lipids and encouraging smoking cessation. Remarkably, for each 1% decrease in hemoglobin A1C, the risk of complications decreases by 28% to 35%, David S. Boyer, MD, an […]

Combining gene therapy and medical device makes progress in RP

Reviewed by José-Alain Sahel, MD An optogenetic treatment, GS030-MD (GenSight Biologics), which combines gene therapy and a medical device, demonstrated a good safety profile in the phase 1/2 PIONEER trial (NCT03326336) n patients with end-stage retinitis pigmentosa (RP), according to José-Alain Sahel, MD. RP, a genetic disease that results from mutations in more than 100 […]

Being the change we want to see in ophthalmology

I am proud to be an ophthalmologist. We are fortunate to be in a field that is at the forefront of technological advancement, research development, and surgical innovation in medicine.  However, though we lead in many aspects, ophthalmology has notoriously lagged behind other medical specialties with regards to diversity, equity, and inclusion. The statistics on […]

Okyo Pharma announces IND filing for OK-101 for the treatment of dry eye disease

Okyo Pharma Ltd., today announced that it filed an Investigational New Drug (IND) application with the FDA for the development of OK-101 to treat dry eye disease (DED). According to the company’s news release, both nonclinical and clinical development plans on OK-101 were reviewed with the FDA in an earlier Pre-IND meeting facilitated by OKYO’s […]

Belite Bio finalizes phase 3 clinical trial plans for advanced dry AMD treatment with LBS-008

Belite Bio Inc. today announced that, following discussions with the FDA, it has finalized the study design for its planned Phase 3 clinical trial to evaluate efficacy and safety of LBS-008 (Tinlarebant) in patients with geographic atrophy (GA) associated with Dry AMD. Tom Lin, MD, CEO of Belite Bio, noted that the company was looking […]

UC Davis tests microshunt in children with refractory childhood glaucoma

A polymer-based microshunt is safe and effective in pediatric patients diagnosed with refractory childhood glaucoma, according to a small, single-center case series at the UC Davis Health Eye Center. According to a UC Davis news release, the study,1 Use of a Novel Microshunt in Refractory Childhood Glaucoma, was published in the American Journal of Ophthalmology. […]

Apellis announces FDA acceptance of NDA amendment and PDUFA date for pegcetacoplan for geographic atrophy

Apellis Pharmaceuticals Inc. today announced that the FDA has accepted the compnay’s unsolicited major amendment to the New Drug Application (NDA) for intravitreal pegcetacoplan for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). According to a news release, the updated Prescription Drug User Fee Act (PDUFA) goal date is February 26, […]

Pipeline shows bright future for combating diabetic eye disease

Reviewed by David S. Boyer, MD When treating diabetic retinopathy (DR) the current approach for physicians remains medical management, specifically maintaining control of blood sugar, blood pressure, and lipids and smoking cessation. Remarkably, for each 1% decrease in the A1c, the risk of complications decreases by 28% to 35%, according to David S. Boyer, MD, […]

Not your typical flight experience

It’s not American or United, but the Orbis Flying Hospital carries on board hope and the gift of sight for patients in need of ophthalmic care around the globe. When it is not on a mission, the MD-10 aircraft often is situated at an airport where the fully accredited teaching facility is put to use […]

World’s Best Eyesight: 5 Ways Animals Outrank Us

Human eyes are complicated, powerful organs, but there are some animals that beat us to the punch when it comes to vision. While it is almost impossible to conclusively rank which animals have the best eyes, because eyesight encompasses such a broad spectrum of attributes, we can look at how some animals have exceptional vision […]

Prevent Blindness declares third annual Thyroid Eye Disease Awareness Week Nov. 14-20

Prevent Blindness has declared Nov. 14-20, 2022, as its third annual “Thyroid Eye Disease Awareness (TED) Week.” TED, sometimes called Graves’ ophthalmopathy or Graves’ eye disease, is an autoimmune disease in which the immune system causes inflammation and swelling and stimulates the production of muscle tissue and fat behind the eye. According to the organization, to help raise […]

Impact of treating AMD before visual function is impaired

Japanese investigators led by first authors Risa Aichi, MD, and Norihiro Nagai, MD, reported that before the best-corrected visual acuity (BCVA) decreases and advanced lesions develop in eyes with age-related macular degeneration (AMD) is the optimal time to begin treatment with anti-vascular endothelial growth factor (VEGF) therapy to obtain better outcomes in the real-world clinic.  Aichi […]

Vision in 3D

So much has to go right as the human visual system develops. One of them is that many thousands of retinal ganglion cells (RGCs) have to relay signals through the eye’s optic nerve via delicate projections, or axons, to precise locations on both sides of the brain that make visual sense of it all, especially […]

Cholesterol and diabetes drugs may lessen risk of degenerative eye disease of aging

Regular use of drugs to lower cholesterol and control type 2 diabetes may lessen the risk of the degenerative eye disease associated with ageing, known as AMD, finds a pooled data analysis of the available evidence, published online in the British Journal of Ophthalmology.1 According to a news release, these common drugs are linked to […]

Nicox outlines future development, partnership plans for NX 470 in glaucoma

Nicox SA today announced future development and partnering plans for NCX 470, a novel nitric oxide (NO)-donating bimatoprost eye drop, currently in Phase 3 development for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. According to a news release, results of the Mont Blanc Phase 3 trial suggests potential commercial opportunity of […]

Retinal camera unlocks back-of-the-eye secrets

An adaptive optics (AO) retinal camera has been used to measure photoreceptors preoperatively and following macular hole (MH) surgery to accurately assess any changes in cone density, according to research presented by Paola L. Oquendo, MD, at the 2022 Canadian Ophthalmological Society Annual Meeting and Exhibition held in Halifax, Nova Scotia, Canada. “We hypothesized that […]

Poor sleep quality may be linked to increased risk of irreversible sight loss

Sleep issues, including too much or too little shut eye, daytime sleepiness, and snoring, may be linked to a heightened risk of developing irreversible sight loss (glaucoma), suggests a large UK Biobank study1 published in the open access journal BMJ Open. According to a news release, the findings underscore the need for sleep therapy in people […]

Proof-of-concept study advances potential new way to deliver gene therapy

A team of Johns Hopkins Medicine researchers say they have successfully used a cell’s natural process for making proteins to “slide” genetic instructions into a cell and produce critical proteins missing from those cells. According to a Johns Hopkins Medicine news release, if further studies verify their proof-of-concept results, the scientists may have a new […]

The Role of Miotic Agents in the Management of Presbyopia

The Role of Miotic Agents in the Management of Presbyopia – Episode 1 October 31, 2022 S. Barry Eiden, OD, FAAO This upcoming program will provide an overview of presbyopia and treatment considerations focusing on mitotic agents from leading experts. Source link

Misinformation rampant about unapproved stem cell therapies

Reviewed by Marissa Patel, BA Intravitreal injections of unapproved stem cell therapies have resulted in irreversible blindness. Lack of patient understanding of stem cell treatments have led to these devastating consequences as a result of predatory practitioners. There currently are no FDA-approved stem cell therapies to treat retinal diseases, and the clinical trials evaluating their […]

Digital home monitoring shows predictive value in disease progression for AMD patients

Notal Vision Inc. this week is reporting on the results of its Analysis of Long-term visual Outcomes of ForeseeHome Remote Telemonitoring (ALOFT) study.1 According to a news release, the 10-year retrospective study details the importance of digital remote monitoring for age-related macular degeneration (AMD) patients.1 The second report specifically focuses on early management and clinical […]

The Perseverance Rover Spies What Appears To Be A Cat On Mars

There are people all over the world that are holding their breath waiting for the next images to come back from Perseverance as it makes its way around Mars, taking pictures and documenting its trip. If you asked any of them what they were least expecting to hear, it’s that a “cat” has been spotted. It really […]

What Is Smile Laser Eye Surgery?

Research shows that laser SMILE eye surgery produces nearly identical visual acuity as LASIK for correction of myopia, without requiring LASIK-style corneal flaps. SMILE (Small Incision Lenticule Extraction) Small Incision Lenticule Extraction) is a type of laser eye surgery intended to correct astigmatism, usually at higher degrees of impairment, in order to improve overall visual […]

Adaptive cataract surgery system streamlines procedure

Video transcript Note: This transcript has been lightly edited for clarity. Harvey Uy, MD, Peregrine Eye and Laser Institute: I’m Dr. Harvey Uy, from the Peregrine Eye and Laser Institute in the Philippines. I have been doing a femtosecond laser-assisted cataract surgery for a decade now. And it is wonderful technology, but it had some limitations. […]

Oculis SA, European Biotech Acquisition Corp. announce business combination agreement

Oculis, SA and European Biotech Acquisition Corp. today announced they have entered into a definitive business combination agreement. According to a news release, upon closing of the transaction, the company will be named Oculis Holding SA and will work to accelerate the development of Oculis’s differentiated ophthalmology pipeline. The companies noted in the news release […]

Woman loses eye after showering while wearing contact lenses and contracting parasite

After showering while wearing her contact lenses, a British woman contracted a persistent parasitic infection that ultimately led to the loss of her left eye. According to a BBC report, Marie Mason, 54, contracted Acanthamoeba keratitis. According to the Centers for Disease Control website, the infection is caused by a microscopic organism that infects the […]

What Is Myopia?

Mild myopia is one of the most common eye disorders, and there are many options for correcting it. Because people with high myopia are at increased risk for developing cataracts, glaucoma, and myopic macular degeneration, managing myopia can help maintain eye health. Because increasing myopia leads to a higher risk of severe eye conditions, specifically […]

Ophthalmologist removes 23 contact lenses from patient’s eye

A California ophthalmologist posted a video of a procedure she performed to remove 23 contact lenses from a woman’s eye, and the video has gone viral, with more than 1 million views. Katarina Kurteeva, MD, a cataract and refractive surgery specialist at California Eye Associates in Newport Beach, California, posted a clip on Instagram showing […]

Celebrating World Sight Day 2022

Led by the International Agency for the Prevention of Blindness (IAPB), the theme for this year’s World Sight Day on October 13 is #LoveYourEyes. Each year, the global awareness day expands in reach, and this year is no different. IAPB’s network of almost 200 members organizations are uniting and inspiring millions of people to help tell […]

How Does Eye Vision Work?

Retina has rods (cells that help you see in low-light conditions) and cones (cells that detect colors). Your retina takes light the eyes are receiving and converts it to nerve signals so that your brain can make sense of what your eyes are seeing. Cells in your retina absorb and convert light to electrochemical impulses […]

3D map reveals DNA organization within human retina cells

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and […]

Eye-opening discovery about adult brain’s ability to recover vision

A discovery about how some visually impaired adults could start to see offers a new vision of the brain’s possibilities. The finding that the adult brain has the potential to partially recover from inherited blindness comes from a collaboration between researchers in the University of California, Irvine School of Biological Sciences and the School of […]

Researchers discover new molecular driver of retinoblastoma

Despite decades of medical advances, children who develop the pediatric eye cancer retinoblastoma often lose their vision or an eye due to a lack of specific, targeted therapies and a poor molecular understanding of the cancer. Now researchers at UT Southwestern and the University of Miami have discovered that a molecule – estrogen-related receptor gamma, […]

How Do Your Eyes Feel?

Myze is a next generation eye care engagement platform that helps identify, treat, and manage dry eyes throughout a patient’s dry eye journey. According to the news release, Myze enables “always available” screenings followed by frictionless access to products, services, and education. No more product overload and decision paralysis at retail locations. Myze makes treating […]

Apellis announces 24-ponth Phase 3 study of pegcetacoplan for GA

Apellis Pharmaceuticals Inc. today announced new data from the 24-month Phase 3 OAKS study of pegcetacoplan, an investigational targeted C3 therapy, for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration. According to the company, two post hoc analyses of microperimetry data showed positive trends with increasing effects over time, demonstrating both monthly […]

ImprimisRx launches compounded Antibiotic Formulation

ImprimisRx today announced the availability of Fortisite, which includes a patent-pending compounded combination of tobramycin 1.5% and vancomycin 5%. According to a news release from the company, compounded topical antibiotic formulations may be appropriate to prescribe for patients with clinical needs that are unmet by FDA-approved drug products. Fortisite, which includes a compounded combination antibiotic formulation […]

How Do Your Eyes Feel?

Myze is a next generation eye care engagement platform that helps identify, treat, and manage dry eyes throughout a patient’s dry eye journey. According to the news release, Myze enables “always available” screenings followed by frictionless access to products, services, and education. No more product overload and decision paralysis at retail locations. Myze makes treating […]

Not enough corneas: Fact or fiction?

Donor corneal tissue for transplantation is something that most US corneal specialists typically do not worry about, because our eye banking system here is the envy of the world. We have many well-regarded, well-established and well-managed organizations doing an incredible job of serving our communities. We can treat our patients with confidence, knowing that we […]

Vision impairment affects earnings and safety in Bangladesh

Reviewed by Jennifer L. Patnaik, PhD Orbis International has focused on vision impairment related to workers in low- and middle-income countries. To no one’s surprise, unaddressed visual problems negatively affect both the level of safety and the earnings of workers in these underdeveloped countries. Simple, readily available solutions can profoundly impact poverty reduction, gender disparities, […]

Eye trauma: Treatment trends and innovations

Jeremy Tan, MD, an oculoplastic surgery specialist at the Dean McGee Eye Institute, details some the latest trends in eye trauma surgery at the Dean McGee Eye Institute, and how these treatments are making an impact on the lives of patients. “Traumas can be functionally disabling and also cosmetically disfiguring,” Tan explained, “We establish function […]

The Importance Of Eye Vision To Americans

From seeing the faces of loved ones, to watching the sun come up and go down — these are a few things that Americans will most miss seeing if they lose sight. A new survey of 2000 Americans found respondents also would miss seeing their childs milestones (26%), nature (23%), their pets (22%), and their […]

How To Find The Best LASIK Surgeon In NYC

Before going in for any type of surgery, you need to consider risks, what to expect, and, above all, how to find a reputable LASIK surgeon. We want to make sure your laser eye surgery is a great experience for you, so we have compiled the reasons why Dr. Sandra Belmont is the best surgeon […]

What Your Eye Color Can Say About Your Health

Researchers found people who had vitiligo were less likely to have blue or grey eyes compared with people who did not. A 2012 review of research on vitiligo published in Nature found the autoimmune disorder, which causes a loss of skin color to mottled patches, was less prevalent in blue-eyed people. You are also a […]

Streamlining stem cells to treat macular degeneration

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems. One of these is age-related macular degeneration, which affects the macula — the back part of the eye that gives us sharp vision and the ability to […]

Aflibercept shown to work at higher dose, longer intervals

Regeneron Pharmaceuticals Inc. this week announced that the primary endpoints were met in two pivotal trials investigating novel aflibercept 8 mg (Eylea) with 12- and 16-week dosing regimens in patients with diabetic macular edema (DME) and wet age-related macular degeneration (wAMD). The PHOTON trial in DME and the PULSAR trial in wAMD both demonstrated that […]

First U.S. patient receives autologous stem cell therapy to treat dry AMD

The National Institutes of Health (NIH) announced the first patient has been treated in its phase 1/2a clinical trial (NCT04339764) of an autologous induced pluripotent stem cell (iPSC) therapy for the treatment of dry age-related macular degeneration (AMD).1 According to an NIH news release, the patient received the therapy as part of a clinical trial […]

Research focuses on retinal issues following COVID-19 infection

Retinal involvement following a COVID-19 infection is rare but can happen after severe infections in immunocompetent individuals, according to Yusar Asad, MD, and colleagues from the Vitreoretinal Services, Centre for Sight, Delhi, India. The research team conducted a retrospective review of consecutive patients presenting with retinal manifestations attributable to COVID 19 between May 2020 and […]

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